{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00906 is a long intergenic non‐coding RNA whose potential role in colorectal cancer (CRC) is suggested by its genomic location. In a recent genome‐wide association study of non‐hereditary CRC in a Spanish population, a novel candidate risk single nucleotide polymorphism (rs3987) was identified at 4q26 (1). Although the study did not directly investigate LINC00906, the 4q26 region in which this SNP is located may encompass regulatory elements—including LINC00906—that could modulate gene expression and, in turn, contribute to CRC susceptibility. Thus, while the functional mechanisms of LINC00906 remain to be elucidated, its proximity to a risk locus supports the hypothesis that it might be involved in the regulation of genes implicated in colorectal tumorigenesis."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luis M Real, Agustín Ruiz, Javier Gayán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0101178"}], "href": "https://doi.org/10.1371/journal.pone.0101178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24978480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24978480"}]}]}]}