{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00908 plays context‐dependent roles in tumor biology. In colorectal cancer, it is upregulated and promotes cell proliferation by modulating cell cycle regulators and suppressing intrinsic apoptosis through activation of caspase‐mediated pathways. In hepatocellular carcinoma, high LINC00908 levels enhance cell migration and viability by binding to and stabilizing the oncogenic transcription factor Sox‐4, thereby contributing to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in prostate cancer LINC00908 is downregulated and functions as a tumor suppressor by competitively binding to miR‑483‑5p, which results in the upregulation of TSPYL5 and inhibition of cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in triple‐negative breast cancer LINC00908 encodes a small regulatory peptide (ASRPS) that binds STAT3, reducing its phosphorylation and subsequent VEGF expression, which in turn limits angiogenesis and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, higher expression of LINC00908 is also associated with advanced tumor grade and poorer prognosis in glioma, highlighting its potential as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Together, these findings underscore the complex and cancer type–specific functions of LINC00908, providing a rationale for its further evaluation as both a biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ti-Dong Shan, Zi-Bin Tian, Qian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic noncoding RNA 00908 promotes proliferation and inhibits apoptosis of colorectal cancer cells by regulating KLF5 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29899"}], "href": "https://doi.org/10.1002/jcp.29899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33020901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33020901"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xinhua Hu, Qingxiang Li, Jinfeng Zhang "}, {"type": "b", "children": [{"type": "t", "text": "The Long Noncoding RNA LINC00908 Facilitates Hepatocellular Carcinoma Progression Via Interaction With Sox-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S216774"}], "href": "https://doi.org/10.2147/CMAR.S216774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31632138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31632138"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Fan, Hai Li, Yun Zhang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00908 negatively regulates microRNA-483-5p to increase TSPYL5 expression and inhibit the development of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-1073-x"}], "href": "https://doi.org/10.1186/s12935-019-1073-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31938018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31938018"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yirong Wang, Siqi Wu, Xun Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20190950"}], "href": "https://doi.org/10.1084/jem.20190950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31816634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31816634"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lianhao Song, Shengkun Zhang, Chenwei Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide identification of lncRNAs as novel prognosis biomarkers of glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29259"}], "href": "https://doi.org/10.1002/jcb.29259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31297871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31297871"}]}]}]}