{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted long non‐coding RNA LINC00909 as a multifaceted oncogenic regulator and promising biomarker in several cancer types. In colorectal cancer, for example, LINC00909 is included in circulating lncRNA panels that exhibit high diagnostic accuracy and prognostic significance, with its levels decreasing after surgical intervention and correlating with autophagy‐related signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in ovarian cancer, elevated tumor and serum levels of LINC00909 are associated with advanced staging and deteriorated patient performance, supporting its role as a non‐invasive diagnostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioma, upregulation of LINC00909 is correlated with higher WHO grade and poorer prognosis. Functional assays indicate that LINC00909 acts as a competitive endogenous RNA (ceRNA) by sponging miR‐194, which in turn leads to the upregulation of MUC1-C and enhanced cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In pediatric acute myeloid leukemia, increased LINC00909 levels promote cell viability, migration, and invasion while inhibiting apoptosis by sequestering miR-625 and modulating the Wnt/β-catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in pediatric acute lymphoblastic leukemia, LINC00909 emerged as a hub RNA associated with disease progression and adverse outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In locally advanced rectal cancer, overexpression of LINC00909 has been linked to increased resistance to chemoradiotherapy, underscoring its potential as a therapeutic target to improve treatment response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings demonstrate that LINC00909 functions as an oncogene by promoting cell proliferation, invasion, and treatment resistance while serving as a promising diagnostic and prognostic biomarker across diverse malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Xu, Gai Zhou, Huizhi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.32747"}], "href": "https://doi.org/10.1002/ijc.32747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31633800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31633800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lin Cheng, Tong Han, Zheyu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of Six Autophagy-related Long Non-coding RNAs as Prognostic Signature in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.49449"}], "href": "https://doi.org/10.7150/ijms.49449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33390777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33390777"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xu Yang, Guixia Wu, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5574130"}], "href": "https://doi.org/10.1155/2021/5574130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34336102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34336102"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhentao Liu, Chengyin Lu, Hongkang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00909 promotes tumor progression in human glioma through regulation of miR-194/MUC1-C axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.108965"}], "href": "https://doi.org/10.1016/j.biopha.2019.108965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31132669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31132669"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lei Ma, Yan-Yan Wang, Peng Jiang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00909 promotes cell proliferation and metastasis in pediatric acute myeloid leukemia via miR-625-mediated modulation of Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.05.001"}], "href": "https://doi.org/10.1016/j.bbrc.2020.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32423818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32423818"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiao-Ying Lin, Ka-Yuk Yuen, Hai-Lei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Potential Biomarkers of Acute Lymphoblastic Leukemia in Children by Using a Competing Endogenous RNA Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/4563523"}], "href": "https://doi.org/10.1155/2022/4563523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35432537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35432537"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yiyi Zhang, Bingjie Guan, Yong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs Associated with Chemoradiotherapy Response and Prognosis in Locally Advanced Rectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inflamm Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/JIR.S334096"}], "href": "https://doi.org/10.2147/JIR.S334096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34866926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34866926"}]}]}]}