{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00917 appears to be a multifunctional long non‐coding RNA implicated in diverse pathological processes. In Alzheimer’s disease research, its locus was identified as nearly genome‐wide significantly associated with cerebrospinal fluid clusterin levels, pointing to a potential role in modulating immune responses and the wound healing process following neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a study of breast cancer mortality, a single nucleotide polymorphism positioned between LINC00917 and FOXF1 was associated with patient survival, suggesting that genetic variation near LINC00917 may influence cancer outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of intervertebral disc degeneration, LINC00917 was found to be differentially expressed and co‐clustered with other transcripts in lncRNA–mRNA regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Functional experimentation further revealed that under oxidative stress conditions, increased LINC00917 expression in nucleus pulposus cells contributes to cytotoxicity, inflammation, and pyroptosis by acting as a competing endogenous RNA that sequesters miR‑149‑5p, thereby modulating NLRP1 expression and promoting degenerative processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, integrative bioinformatics analyses in colorectal cancer have identified LINC00917 as part of core non‐coding RNA networks associated with tumor progression, underscoring its potential utility as a molecular biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Collectively, these studies indicate that LINC00917 may function in regulating immune activity, inflammatory responses, and cell fate decisions across several diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuetiva Deming, Jian Xia, Yefei Cai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Potential Role of lncRNAs in Contributing to Pathogenesis of Intervertebral Disc Degeneration Based on Microarray Data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.894638"}], "href": "https://doi.org/10.12659/msm.894638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26556537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26556537"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tengfei Li, Ye Peng, Yufei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-coding RNA -00917 regulates the proliferation, inflammation, and pyroptosis of nucleus pulposus cells via targeting miR-149-5p/NOD-like receptor protein 1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2043100"}], "href": "https://doi.org/10.1080/21655979.2022.2043100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35184666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35184666"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fahimeh Fattahi, Jafar Kiani, Mohsen Khosravi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enrichment of Up-regulated and Down-regulated Gene Clusters Using Gene Ontology, miRNAs and lncRNAs in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207321666191010114149"}], "href": "https://doi.org/10.2174/1386207321666191010114149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31654507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31654507"}]}]}]}