{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted context‐dependent roles for the long noncoding RNA LINC00920. In non‐small cell lung cancer (NSCLC), LINC00920—also known as LINRIS—is upregulated in tumor tissues and is associated with poor patient survival outcomes. Functional analyses indicate that LINC00920 promotes NSCLC cell proliferation by enhancing the maturation of microRNA-10a; silencing LINC00920 leads to reduced levels of mature miR-10a and consequently inhibits cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, transcriptomic analyses in prostate cancer have linked overexpression of LINC00920 with a better outcome in patients undergoing hormone regimens, suggesting a more favorable prognostic role in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, earlier investigations into the transcriptome of early onset prostate cancer have pointed to the discovery of novel noncoding RNAs, underscoring the growing recognition of lncRNAs like LINC00920 in the modulation of cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yajie Zhu, Ke Ma, Yingxue Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINRIS is upregulated in non-small cell lung cancer and its silencing inhibits cell proliferation by suppressing microRNA-10a maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2031672"}], "href": "https://doi.org/10.1080/21655979.2022.2031672"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35137650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35137650"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Simona De Summa, Antonio Palazzo, Mariapia Caputo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA Landscape in Prostate Cancer Molecular Subtypes: A Feature Selection Approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22042227"}], "href": "https://doi.org/10.3390/ijms22042227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33672425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33672425"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Arlou Kristina Angeles, Doreen Heckmann, Niclas Flosdorf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ERG-Regulated "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00920"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Promotes Prostate Cancer Cell Survival via the 14-3-3ε-FOXO Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-20-0021"}], "href": "https://doi.org/10.1158/1541-7786.MCR-20-0021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32646965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32646965"}]}]}]}