{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLINC00921 functions as an oncogenic long non‐coding RNA that plays a central role in modulating alternative polyadenylation (APA) events in non‐small cell lung cancer (NSCLC). Induced by MED13L/P300, LINC00921 regulates the stability of NUDT21 by facilitating its binding with the E3 ubiquitin ligase TRIP12. This process destabilizes NUDT21, which in turn promotes 3′ untranslated region shortening of MED23 mRNA via APA. The resulting increase in MED23 protein levels triggers nuclear translocation of β‑catenin and activation of key oncogenic factors—including c‑Myc, CCND1, and BMP4—thereby reducing tumor radiosensitivity and correlating with poor prognoses in NSCLC patients receiving radiotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nLINC00921 also exhibits clinical relevance in lung adenocarcinoma (LUAD), where its expression is significantly lower in tumor tissues compared to non‑tumorous counterparts. In LUAD, diminished LINC00921 expression is associated with decreased immune cell infiltration in the tumor microenvironment, distinct tumor mutational burden profiles, and a shorter median overall survival. These findings suggest that LINC00921 may regulate target gene transcription and potentially serve as a diagnostic and prognostic biomarker for LUAD, with implications for therapeutic strategies including those targeting metabolic pathways related to glyceraldehyde‑3‑phosphate dehydrogenase."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nCollectively, these studies underscore the multifaceted roles of LINC00921 in lung cancer pathogenesis: by orchestrating APA‐mediated oncogene activation in NSCLC and by serving as a potential biomarker in LUAD. Understanding the mechanistic underpinnings of LINC00921’s regulatory functions not only broadens our insight into lncRNA‐mediated gene expression but also highlights its promise as both a therapeutic target and clinical indicator in advanced lung cancer.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nasha Zhang, Xijun Liu, Linying Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2023.113479"}], "href": "https://doi.org/10.1016/j.celrep.2023.113479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37999979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37999979"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongyu Xu, Weijie Xiong, Xianguo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00921 serves as a predictive biomarker for lung adenocarcinoma: An observational study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000037179"}], "href": "https://doi.org/10.1097/MD.0000000000037179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38363898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38363898"}]}]}]}