{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00922 has emerged as a key oncogenic long non‐coding RNA with diverse roles in tumor progression and chemoresistance across multiple disease contexts. In breast cancer, for instance, LINC00922 is overexpressed and promotes tumor growth and metastasis by recruiting DNA methyltransferases to hypermethylate the NKD2 promoter, which in turn activates Wnt signaling and facilitates epithelial–mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LINC00922 functions as a competing endogenous RNA (ceRNA) by sponging miR‑424‑5p, thereby derepressing ARK5 to enhance cell viability, migration, invasion, and EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In ovarian cancer, LINC00922 similarly acts through a ceRNA mechanism by competitively binding with miR‑361‑3p to relieve its suppression of CLDN1, which leads to activation of Wnt/β‑catenin signaling and subsequent tumorigenesis and EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In osteosarcoma, LINC00922 upregulation has been linked to doxorubicin resistance and poorer clinical outcomes, underscoring its clinical relevance in chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In gastric cancer, multiple studies indicate that LINC00922 exerts oncogenic effects by sponging distinct microRNAs. For example, its interaction with miR‑874‑3p modulates GDPD5 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and its sequestration of miR‑204‑5p results in upregulation of HMGA2, thereby promoting cell proliferation, migration, invasion, and EMT."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " In lung cancer, LINC00922 is also overexpressed and contributes to enhanced proliferation, migration, and invasion via regulation of the miR‑204/CXCR4 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Beyond oncology, elevated LINC00922 expression in placental trophoblasts has been associated with increased cell proliferation and invasive capability in preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings highlight that LINC00922 functions as a critical regulator of oncogenic processes—including activation of key signaling pathways, promotion of EMT, and contribution to chemoresistance—and suggest that it may serve as a promising prognostic biomarker and therapeutic target across a range of pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Wang, Tianfu Dong, Peishun Wang, et al. 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