{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the abstracts provide a detailed mechanistic role for LINC00923, one study focused on head and neck squamous cell carcinoma (HNSCC) identified LINC00923 as a candidate long non‐coding RNA whose expression was significantly associated with patient survival. In that study, RNA‑sequencing analysis of HNSCC tissue samples revealed that among several lncRNAs showing differential expression, LINC00923 was one of five (along with KTN1‑AS1, LINC00460, GUSBP11, and RP5‑894A10.6) initially selected as potential prognostic biomarkers. However, when the authors refined their prognostic model, a panel comprising KTN1‑AS1, LINC00460, and RP5‑894A10.6 provided the highest predictive accuracy for overall survival, which suggests that while LINC00923 may be involved in the molecular landscape of HNSCC, its prognostic impact was less robust compared to the other candidates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n The remaining abstracts addressed chronic inflammatory states and chronic kidney disease (CKD) progression but did not elaborate on the specific biological function or clinical relevance of LINC00923. As such, while LINC00923 appears as a molecule of interest in the context of cancer prognosis, particularly HNSCC, additional research is needed to clarify its precise function and potential as a biomarker in other diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Cao, Jian-Nan Liu, Zeqi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A three-lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.oraloncology.2016.12.017"}], "href": "https://doi.org/10.1016/j.oraloncology.2016.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28109476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28109476"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mehmet Kanbay, Aslihan Yerlikaya, Alan A Sag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A journey from microenvironment to macroenvironment: the role of metaflammation and epigenetic changes in cardiorenal disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Kidney J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ckj/sfz106"}], "href": "https://doi.org/10.1093/ckj/sfz106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31807301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31807301"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Afshin Parsa, Peter A Kanetsky, Rui Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2015101152"}], "href": "https://doi.org/10.1681/ASN.2015101152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27729571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27729571"}]}]}]}