{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00924 has been implicated in multiple malignancies with context‐dependent roles. In hepatitis B virus–related hepatocellular carcinoma, reduced LINC00924 expression is associated with poor clinical outcomes. Experimental data indicate that LINC00924 acts as a tumor suppressor by inhibiting cell invasion and the epithelial–mesenchymal transition via a mechanism involving the sponging of miR‑6755‑5p, which in turn elevates NDRG2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in the context of advanced gastric cancer with peritoneal metastasis, LINC00924 is up‑regulated, especially when gastric cancer cells are exposed to an adipocyte‐rich environment that mimics the peritoneal microenvironment. Elevated LINC00924 in this setting is significantly associated with reduced overall survival, altered tumor immune infiltration (notably CD8+ cells), and a poorer response to immune checkpoint blockade therapies, suggesting that it may serve as a potential immunotherapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in thyroid cancer, lower expression of LINC00924 correlates with longer disease‑free survival. Bioinformatics analyses have implicated LINC00924, along with other long noncoding RNAs, in the regulation of processes such as RNA metabolism, cell migration, and organelle assembly, highlighting its potential as a biomarker for disease prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although differential gene expression analyses in conditions such as Hirschsprung’s disease have been performed"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the specific role of LINC00924 in this developmental disorder remains to be further elucidated.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kai Yu, Yunhua Mei, Zhongyi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00924 upregulates NDRG2 to inhibit epithelial-mesenchymal transition via sponging miR-6755-5p in hepatitis B virus-related hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jmv.27578"}], "href": "https://doi.org/10.1002/jmv.27578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34997970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34997970"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Fang, Sihao Huang, Lei Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Peritoneal Metastasis Sequencing Data to Identify LINC00924 as a Prognostic Biomarker in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S318704"}], "href": "https://doi.org/10.2147/CMAR.S318704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34285580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34285580"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuansheng Rao, Haiying Liu, Xiaojuan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Silico Analysis Identifies Differently Expressed lncRNAs as Novel Biomarkers for the Prognosis of Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3651051"}], "href": "https://doi.org/10.1155/2020/3651051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32377223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32377223"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoguang Niu, Yongtao Xu, Ni Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Weighted Gene Coexpression Network Analysis Reveals the Critical lncRNAs and mRNAs in Development of Hirschsprung's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comput Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cmb.2019.0261"}], "href": "https://doi.org/10.1089/cmb.2019.0261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31647312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31647312"}]}]}]}