{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00926 has emerged as a multifunctional regulator in both cancer and inflammatory diseases. In breast cancer, LINC00926 functions as a tumor suppressor by downregulating the glycolytic enzyme PGK1; it enhances PGK1 ubiquitination via the E3 ligase STUB1 and forms part of a FOXO3A‐mediated regulatory axis that modulates glycolysis, tumor growth, and metastasis, with higher LINC00926 levels correlating with better clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, in the context of post‐traumatic stress disorder, upregulation of LINC00926 promotes the recruitment of the histone methyltransferase MLL1 to the WNT10B promoter, thereby increasing H3K4 trimethylation and the expression of inflammatory cytokines such as IFNG and IL17A."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, LINC00926 appears as a protective factor in prognostic models based on lipid metabolism‐related long non‐coding RNAs in breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and is also included in an immune infiltration‐associated lncRNA signature that independently correlates with overall survival in colon cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhong Chu, Nan Huo, Xiang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXO3A-induced LINC00926 suppresses breast tumor growth and metastasis through inhibition of PGK1-mediated Warburg effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2021.04.036"}], "href": "https://doi.org/10.1016/j.ymthe.2021.04.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33940159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33940159"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marpe Bam, Xiaoming Yang, Jay P Ginsberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-022-01971-5"}], "href": "https://doi.org/10.1038/s41398-022-01971-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35551428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35551428"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guo-Jian Shi, Qin Zhou, Qi Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel prognostic model associated with the overall survival in patients with breast cancer based on lipid metabolism-related long noncoding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24384"}], "href": "https://doi.org/10.1002/jcla.24384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35441740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35441740"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanbo Wang, Jing Liu, Fenghai Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of a Four-Long Non-coding RNA Signature Associated With Immune Infiltration and Prognosis in Colon Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.671128"}], "href": "https://doi.org/10.3389/fgene.2021.671128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34290738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34290738"}]}]}]}