{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNAs (lncRNAs) are increasingly recognized as pivotal regulators in various human diseases by modulating gene expression and cellular metabolism. In nasopharyngeal carcinoma (NPC), LINC00930 is markedly upregulated and correlates with tumorigenesis, lymphatic invasion, metastasis, and poor patient prognosis. Mechanistic studies have shown that LINC00930 acts as a molecular scaffold, recruiting the RBBP5 and GCN5 complex to the promoter of PFKFB3. This recruitment enhances H3K4 trimethylation and H3K9 acetylation, leading to epigenetic transactivation of PFKFB3, increased glycolytic flux, and accelerated cell cycle progression, ultimately driving oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although not directly highlighted in its functional studies, lncRNAs as a group—including candidates like LINC00930—have been implicated in regulating competing endogenous RNA (ceRNA) networks in muscle-invasive bladder cancer, thereby influencing tumorigenesis and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, machine learning analyses investigating chronic obstructive pulmonary disease (COPD) have identified LINC00930 among a panel of novel candidate genes associated with lung function regulation and COPD pathogenesis, broadening the potential clinical relevance of this lncRNA beyond oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the multifaceted role of LINC00930 in promoting oncogenic metabolic reprogramming via epigenetic regulation and suggest its potential as a biomarker and therapeutic target across a spectrum of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Baoyu He, Hongli Pan, Fengque Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-022-02282-9"}], "href": "https://doi.org/10.1186/s13046-022-02282-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35209949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35209949"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hanbo Wang, Leilei Niu, Shaobo Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA network in muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13363"}], "href": "https://doi.org/10.18632/oncotarget.13363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27863388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27863388"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shayan Mostafaei, Anoshirvan Kazemnejad, Sadegh Azimzadeh Jamalkandi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Novel Genes in Human Airway Epithelial Cells associated with Chronic Obstructive Pulmonary Disease (COPD) using Machine-Based Learning Algorithms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-33986-8"}], "href": "https://doi.org/10.1038/s41598-018-33986-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30361509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30361509"}]}]}]}