{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00936, a long intergenic noncoding RNA, exhibits distinct and context‐dependent functions across disease settings. In gastric cancer, reduced levels of LINC00936 correlate with enhanced immune escape of cancer cells. Upregulation of LINC00936 inhibits this immune escape through modulation of the miR‑425‑3p/ZC3H12A axis, which in turn is associated with increased CD3 expression, suggesting a potential role in promoting antitumor immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In ovarian cancer, LINC00936 functions as a competitive endogenous RNA by binding miR‑221‑3p to regulate the expression of the laminin alpha 3 chain gene (LAMA3). Overexpression of LINC00936 leads to decreased miR‑221‑3p levels and consequent upregulation of LAMA3, thereby suppressing cell proliferation, migration, invasion, angiogenesis, and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in the context of myocardial infarction, LINC00936 is upregulated, and its overexpression exacerbates myocardial injury by promoting apoptosis and reactive oxygen species accumulation in hypoxic cardiomyocytes. This detrimental effect is mediated via sponging miR‑4795‑3p, which results in increased Wnt3a expression and further aggravation of cardiac cell damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that while LINC00936 acts as a tumor suppressor in several cancers by functioning as a ceRNA, its role in myocardial infarction appears to be injurious. This context‐dependent functionality underscores its potential as both a biomarker and a therapeutic target in diverse pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haohao Li, Chunlin Zhao, Hongchao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated linc00936 or silenced microRNA-425-3p inhibits immune escape of gastric cancer cells via elevation of ZC3H12A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.107559"}], "href": "https://doi.org/10.1016/j.intimp.2021.107559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33756228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33756228"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chenggan Shu, Weiwei Wang, Lipei Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Recent Pat Anticancer Drug Discov (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1574892817666220316152201"}], "href": "https://doi.org/10.2174/1574892817666220316152201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35297352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35297352"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lvyun Xu, Fan Wang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00936 exacerbated myocardial infarction progression via miR-4795-3p/Wnt3a signaling pathway based on biological and imaging methods."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Perfusion (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/02676591221076788"}], "href": "https://doi.org/10.1177/02676591221076788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35410528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35410528"}]}]}]}