{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00937 has emerged as an important long non‐coding RNA with diverse roles in disease pathogenesis and prognosis. In keloids, decreased levels of LINC00937 in fibroblasts result in enhanced extracellular matrix deposition and cell proliferation, whereas its overexpression represses these processes via acting as a sponge for miR‑28‑5p and thereby upregulating MC1R expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Additionally, integrated bioinformatics analyses have identified LINC00937 as part of a competing endogenous RNA network in cutaneous melanoma, where its expression is strongly associated with patients’ prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of subarachnoid hemorrhage resulting from ruptured intracranial aneurysm, LINC00937 was found within a co‑expression network correlated with key regulatory pathways including cytokine–cytokine receptor interactions, neurotrophin signaling, and apoptosis, suggesting its potential involvement in these critical processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in anaplastic gliomas, LINC00937 contributes to an immune‑related lncRNA signature that stratifies patients based on overall survival and progression‐free survival, underscoring its promise as a prognostic biomarker and potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Wan, Xiao-Lei He, Qi-Chao Jian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00937 suppresses keloid fibroblast proliferation and extracellular matrix deposition by targeting the miR-28-5p/MC1R axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-372"}], "href": "https://doi.org/10.14670/HH-18-372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34486677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34486677"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Siyi Xu, Jing Sui, Sheng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of competing endogenous RNA network focusing on long noncoding RNA associated with progression of cutaneous melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1315"}], "href": "https://doi.org/10.1002/cam4.1315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29522273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29522273"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Leng, Dan Fan, Zhong Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12883-021-02156-1"}], "href": "https://doi.org/10.1186/s12883-021-02156-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33990177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33990177"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wen Wang, Zheng Zhao, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An immune-related lncRNA signature for patients with anaplastic gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-017-2667-6"}], "href": "https://doi.org/10.1007/s11060-017-2667-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29170907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29170907"}]}]}]}