{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent comprehensive analysis of Burkitt lymphoma (BL) genomes and transcriptomes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", multiple layers of genomic deregulation were identified, including MYC oncogene dysregulation mediated by translocations, fusion transcripts, and alternative splicing events. Although the study did not explicitly detail the function of LINC00939, its inclusion among the catalog of perturbed transcripts in BL suggests that this long non‐coding RNA may play a regulatory role. In this context, LINC00939 could contribute to the oncogenic program in BL by modulating transcriptional networks or interacting with other driver genes implicated in MYC dysregulation. Such a role is consistent with the emerging concept that non‐coding RNAs may influence oncogenesis through their involvement in chromatin remodeling, transcriptional regulation, and the stabilization or generation of fusion transcripts. Further functional studies are warranted to clarify the precise mechanisms by which LINC00939 interfaces with the complex interplay of structural, mutational, and transcriptional alterations observed in BL."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cristina López, Kortine Kleinheinz, Sietse M Aukema, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-08578-3"}], "href": "https://doi.org/10.1038/s41467-019-08578-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30926794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30926794"}]}]}]}