{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies of long noncoding RNAs have revealed their diverse roles in disease pathogenesis. One study on asthma focused on the lncRNA PVT1—which was markedly decreased in corticosteroid‐sensitive nonsevere asthma but increased in corticosteroid‐insensitive severe asthma—and demonstrated that PVT1 regulates airway smooth muscle cell proliferation and cytokine release."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, a separate investigation into glioma prognostics identified LINC00940 as one of five lncRNAs that were significantly differentially expressed between glioma patients with favorable and poor outcomes. LINC00940 was incorporated into a risk assessment model that robustly predicts patient survival, and co‑expression network analysis linked it to genes involved in cytoskeleton organization, cell adhesion, and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Thus, while the asthma study highlights the functional importance of lncRNAs in modulating airway smooth muscle cell behavior, the glioma study suggests that LINC00940 may serve as a valuable biomarker and potential regulator in tumor biology and prognosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Philip J Austin, Eleni Tsitsiou, Charlotte Boardman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2016.06.014"}], "href": "https://doi.org/10.1016/j.jaci.2016.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27484035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27484035"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chenggong Hu, Yongfang Zhou, Chang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Risk assessment model constructed by differentially expressed lncRNAs for the prognosis of glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6639"}], "href": "https://doi.org/10.3892/or.2018.6639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106138"}]}]}]}