{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00941 is a long non‐coding RNA that has emerged as a pivotal oncogenic regulator in several solid tumors. It is frequently up‐regulated in cancer tissues compared with normal counterparts and is associated with larger tumor size, advanced clinical stage, enhanced invasion and metastasis, as well as poor patient prognosis. In pancreatic cancer, for instance, LINC00941 acts as a competing endogenous RNA (ceRNA) by sponging microRNAs (such as miR‐335‐5p), thereby facilitating the upregulation of targets like ROCK1 and activating downstream pathways (e.g., the LIMK1/Cofilin-1 cascade) that promote cell growth and metastatic spread."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oral squamous cell carcinoma, LINC00941 is transcriptionally activated through EP300-mediated histone acetylation, which in turn elevates CAPRIN2 expression and triggers the canonical WNT/β-catenin signaling pathway, resulting in augmented proliferation and colony formation of tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, LINC00941 has been shown to bind directly to the MH2 domain of SMAD4 and protect it from degradation by competing with ubiquitin ligases; this action enhances TGF-β/SMAD2/3 signaling and drives epithelial-mesenchymal transition (EMT), thereby accelerating metastatic dissemination, including lung colonization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies have incorporated LINC00941 in multi-lncRNA prognostic signatures for cancers such as lung adenocarcinoma and head and neck squamous cell carcinoma, reinforcing its clinical value as a biomarker for aggressive disease and poor outcome. Moreover, in colon cancer models, LINC00941 was demonstrated to promote tumor progression by modulating the miR-205-5p/MYC axis, further underscoring its role as a key facilitator of malignant behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings reveal that LINC00941 contributes to tumorigenesis by regulating key processes such as cell proliferation, migration, invasion, and EMT through distinct molecular mechanisms in various cancer types, and they highlight its potential utility as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jie Wang, Zhiwei He, Jian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03316-w"}], "href": "https://doi.org/10.1038/s41419-020-03316-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33414429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33414429"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Fang, S-H Wang, Y-G Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00941 promotes proliferation and metastasis of pancreatic adenocarcinoma by competitively binding miR-873-3p and thus upregulates ATXN2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202102_25081"}], "href": "https://doi.org/10.26355/eurrev_202102_25081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33660796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33660796"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yilong Ai, Siyuan Wu, Chen Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00941 promotes oral squamous cell carcinoma progression via activating CAPRIN2 and canonical WNT/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15667"}], "href": "https://doi.org/10.1111/jcmm.15667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32691935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32691935"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Liu, Zhenxing Li, Ting Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutr Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/01635581.2022.2027473"}], "href": "https://doi.org/10.1080/01635581.2022.2027473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35037538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35037538"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nan Wu, Mingzuo Jiang, Haiming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-020-0596-y"}], "href": "https://doi.org/10.1038/s41418-020-0596-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32737443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32737443"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lin Chang, Dongmin Zhou, Suxia Luo "}, {"type": "b", "children": [{"type": "t", "text": "Novel lncRNA LINC00941 Promotes Proliferation and Invasion of Colon Cancer Through Activation of MYC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S293519"}], "href": "https://doi.org/10.2147/OTT.S293519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33654409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33654409"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Min-Huan Ren, Si Chen, Liang-Ge Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00941 Promotes Progression of Non-Small Cell Lung Cancer by Sponging miR-877-3p to Regulate VEGFA Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.650037"}], "href": "https://doi.org/10.3389/fonc.2021.650037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33869051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33869051"}]}]}]}