{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00942 is increasingly recognized as an oncogenic long non‐coding RNA whose aberrant up‐regulation has been observed in multiple human cancers, including lung adenocarcinoma, hepatocellular carcinoma, clear cell renal cell carcinoma, and gastric cancer. In lung adenocarcinoma, for example, LINC00942 acts as a competing endogenous RNA (ceRNA) by sequestering miR‑5006‑5p. This sequestration relieves the repression of FZD1 and thereby promotes Wnt/β‑catenin signaling, which in turn enhances cell proliferation, migration, and invasion while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LINC00942 has been identified as a key component of multiple prognostic and diagnostic ceRNA networks. It is incorporated into panels—such as ferroptosis‑ and immune‑related lncRNA signatures—in hepatocellular carcinoma and other tumor types, underscoring its potential as a biomarker for disease progression and patient outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in gastric cancer, elevated levels of LINC00942 (also referred to as LNC942) have been linked to chemoresistance. Here, increased expression of LINC00942 impairs cellular apoptosis and promotes cancer stemness by up‑regulating the RNA binding protein MSI2, thereby contributing to resistance against cisplatin‑based chemotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similar observations have been noted in the context of clear cell renal cell carcinoma, where LINC00942 is part of a ceRNA network associated with enhanced malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, beyond oncogenesis, genomic alterations involving LINC00942 have been reported in neurodevelopmental disorders such as autism spectrum disorder, although its direct mechanistic contribution in this context remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ronghua Wang, Xiuyun Wang, Jingtao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00942 Promotes Tumor Proliferation and Metastasis in Lung Adenocarcinoma via FZD1 Upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820977526"}], "href": "https://doi.org/10.1177/1533033820977526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34253104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34253104"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huihui Hu, Hangdi Xu, Fen Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploring the Effect of Differentially Expressed Long Non-coding RNAs Driven by Copy Number Variation on Competing Endogenous RNA Network by Mining Lung Adenocarcinoma Data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2020.627436"}], "href": "https://doi.org/10.3389/fcell.2020.627436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33585468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33585468"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yimeng Cui, Yaowen Cui, Ruixue Gu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Ferroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-10508-1"}], "href": "https://doi.org/10.1038/s41598-022-10508-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35459272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35459272"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhijie Xu, Bi Peng, Qiuju Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a Ferroptosis-Related Nine-lncRNA Signature for Predicting Prognosis and Immune Response in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.719175"}], "href": "https://doi.org/10.3389/fimmu.2021.719175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34603293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34603293"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qianhui Xu, Yuxin Wang, Wen Huang "}, {"type": "b", "children": [{"type": "t", "text": "Identification of immune-related lncRNA signature for predicting immune checkpoint blockade and prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.107333"}], "href": "https://doi.org/10.1016/j.intimp.2020.107333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33486322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33486322"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yiran Zhu, Bingluo Zhou, Xinyang Hu, et al. 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