{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00943 is a long intergenic non‐coding RNA that has emerged as an important regulatory molecule in diverse diseases. In the context of Parkinson’s disease, several studies have demonstrated that LINC00943 is markedly up‐regulated in toxin‐induced models (using MPP⁺/MPTP), where its elevated expression is associated with neuronal injury. Mechanistically, LINC00943 appears to function as a competing endogenous RNA that sponges microRNAs (such as miR‑338‑3p and miR‑7‑5p), thereby modulating downstream effectors (including SP1 and CXCL12) involved in inflammation, oxidative stress, and apoptosis; accordingly, knockdown of LINC00943 alleviates neurodegeneration and may represent a potential therapeutic strategy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oncology, LINC00943 has been identified as a hub gene in the competitive endogenous RNA network of cutaneous melanoma, where its dysregulated expression is closely linked to tumorigenesis and serves as an independent prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in clear cell renal cell carcinoma, LINC00943 is integrated into a prognostic risk model based on ceRNA interactions, suggesting its involvement in disease pathogenesis and its potential utility as a biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in gastric cancer, overexpression of LINC00943 correlates with poor patient prognosis; functional studies indicate that LINC00943 promotes cancer cell proliferation and chemoresistance by regulating hsa‑miR‑101‑3p, an interaction that may offer new avenues for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chunming Meng, Jing Gao, Qingyuan Ma, et al. 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