{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00944 has emerged as a potentially important regulator in cancer through its involvement in both immune modulation and tumor progression. In breast cancer, LINC00944 expression is regulated by the RNA‐editing enzyme ADAR1, with its up‐ or downregulation being closely linked to immune signaling pathways. Notably, higher levels of LINC00944 are strongly correlated with increased tumor-infiltrating T lymphocytes, elevated pro-apoptotic markers, and clinical features such as tumor size and hormone receptor status; furthermore, reduced expression of LINC00944 is associated with poorer patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In renal cell carcinoma, LINC00944 is significantly overexpressed in patient tissues and cell lines, with high levels correlating with advanced tumor stage and unfavorable survival outcomes. Functional assays demonstrated that knocking down LINC00944 impairs cell proliferation and migration while modulating Akt phosphorylation, indicating an oncogenic role in RCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pamela R de Santiago, Alejandro Blanco, Fernanda Morales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118956"}], "href": "https://doi.org/10.1016/j.lfs.2020.118956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33383047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33383047"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chiheng Chen, Hanxiong Zheng "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00944 Promotes Tumorigenesis but Suppresses Akt Phosphorylation in Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2021.697962"}], "href": "https://doi.org/10.3389/fmolb.2021.697962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34291088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34291088"}]}]}]}