{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent multi‐cancer studies have increasingly implicated the long noncoding RNA LINC00957 as a prognostic biomarker and potential regulator of tumor biology. In colorectal cancer, for example, LINC00957 is significantly upregulated and its elevated expression is associated with advanced TNM stage, poorer chemotherapy outcomes, and reduced overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In osteosarcoma, LINC00957 was identified as part of a seven‐RNA prognostic signature where its expression correlated with recurrence and adverse survival, highlighting its potential utility in risk prediction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in low‐grade glioma, LINC00957 appears as one of nine autophagy-related lncRNAs that can stratify patients into high- and low-risk groups, thereby serving as an independent prognostic factor and suggesting a role in the regulation of autophagy-linked tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, in clear cell renal cell carcinoma investigations exploring competing endogenous RNA (ceRNA) networks, LINC00957 was among several lncRNAs selected for prognostic modeling, which implies that it may contribute to the modulation of mRNA expression via ceRNA interactions, even though its precise mechanistic role in this context remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that LINC00957 is aberrantly expressed in diverse tumor types and likely plays a multifaceted role in promoting tumor progression—possibly by influencing ceRNA interactions and autophagy-associated pathways. As such, LINC00957 holds promise as a prognostic biomarker that may inform patient stratification and personalized therapeutic strategies across cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Hua Zhang, Long Hai Li, Peng Fei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00957 Acted as Prognostic Marker Was Associated With Fluorouracil Resistance in Human Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.00776"}], "href": "https://doi.org/10.3389/fonc.2019.00776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31497531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31497531"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Minglei Zhang, Yang Liu, Daliang Kong "}, {"type": "b", "children": [{"type": "t", "text": "Identifying biomolecules and constructing a prognostic risk prediction model for recurrence in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbo.2020.100331"}], "href": "https://doi.org/10.1016/j.jbo.2020.100331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33376666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33376666"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aierpati Maimaiti, Mirezhati Tuerhong, Yongxin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An innovative prognostic model based on autophagy-related long noncoding RNA signature for low-grade glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-022-04368-6"}], "href": "https://doi.org/10.1007/s11010-022-04368-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35152365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35152365"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hang Yin, Xiaoyuan Wang, Xue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of long noncoding RNA associated-competing endogenous RNA as prognostic biomarkers in clear cell renal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13778"}], "href": "https://doi.org/10.1111/cas.13778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30152187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30152187"}]}]}]}