{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00958 is a long non‐coding RNA that is aberrantly upregulated in a wide variety of human cancers and other disease conditions, where it functions as an oncogenic regulator by modulating diverse cellular processes. In malignant settings such as hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", bladder cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", glioma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", pancreatic cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", cervical cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", oral and tongue squamous cell carcinomas"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and nasopharyngeal carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", LINC00958 promotes tumorigenesis by enhancing proliferation, migration, invasion, and epithelial–mesenchymal transition; it also contributes to treatment resistance. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC00958 frequently serves as a competing endogenous RNA (ceRNA), “sponging” several tumor‐suppressive microRNAs—including miR-3619-5p, miR-625-5p, miR-203, miR-185-5p, miR-211-5p, and miR-204-3p—and thereby derepressing the expression of downstream oncogenes (e.g., HDGF, LRRC8E, CDK2, PAX8, YWHAZ, CENPK, KIF2A, NUAK1, and MAPK1). These interactions lead to activation of key signaling pathways, such as JNK/c-JUN, AKT/mTOR, and PI3K/AKT, which further drive tumor progression and aggressive phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its oncogenic roles, LINC00958 is also implicated in non-malignant pathologies. For example, in intervertebral disc degeneration, elevated LINC00958 promotes nucleus pulposus cell proliferation and extracellular matrix degradation by sponging miR-203 and upregulating targets such as SMAD3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight the pivotal role of LINC00958 as a multifunctional regulator—serving not only as a promising prognostic biomarker but also as a potential therapeutic target across a broad spectrum of cancers and degenerative diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xueliang Zuo, Zhiqiang Chen, Wen Gao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Silencing of long noncoding RNA LINC00958 prevents tumor initiation of pancreatic cancer by acting as a sponge of microRNA-330-5p to down-regulate PAX8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.12.017"}], "href": "https://doi.org/10.1016/j.canlet.2018.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30639194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30639194"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lifeng Wang, Yanbo Zhong, Baohua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00958 facilitates cervical cancer cell proliferation and metastasis by sponging miR-625-5p to upregulate LRRC8E expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29472"}], "href": "https://doi.org/10.1002/jcb.29472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31691355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31691355"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zongsheng Wang, Xuemei Zhu, Pengfei Dong, et al. 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