{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00960 has emerged as a multifunctional long non‐coding RNA that contributes to tumor progression and other pathological conditions through diverse regulatory mechanisms. In several cancer types—including bladder cancer, osteosarcoma, lung adenocarcinoma, and pancreatic ductal adenocarcinoma—LINC00960 is upregulated and enhances malignant behaviors such as cell viability, proliferation, migration, invasion, clonogenicity, and the epithelial‐mesenchymal transition. In high‐grade bladder cancer, for example, exosome‐derived LINC00960 increases the aggressiveness of recipient cancer cells by upregulating key EMT‐initiating signaling pathways (β‐catenin, Notch, and Smad2/3)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In osteosarcoma, LINC00960 acts as an oncogene by sponging miR‐107 to elevate SALL4 expression and promote tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung adenocarcinoma, increased LINC00960 sequesters miR‐124a, thereby modulating the SphK1/S1P signaling axis to foster tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in pancreatic ductal adenocarcinoma, LINC00960 promotes oncogenesis by acting as a competitive endogenous RNA (ceRNA) for miR‐146a‐5p, which results in elevated IRAK1 levels and enhanced cellular aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its oncogenic roles, LINC00960 forms components of ceRNA networks in other diseases. In the context of schizophrenia, LINC00960 is implicated in a ceRNA axis with miR‐34a‐5p and FOSL1, suggesting a potential role in neurodevelopmental regulatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in diabetic nephropathy, LINC00960 participates in a ceRNA network influencing MMP‐2 expression by interacting with hsa‐miR‐1237‐3p, thereby linking it to renal injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LINC00960 has been identified as part of prognostic signatures in bladder urothelial carcinoma and pancreatic ductal adenocarcinoma, underscoring its potential as a diagnostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, in idiopathic pulmonary fibrosis, LINC00960 is upregulated in lung fibroblasts and functions as a positive regulator of cell proliferation, highlighting its relevance in conditions characterized by tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, the current studies demonstrate that LINC00960 acts as a promoter of disease progression by modulating critical signaling pathways through miRNA sponging and ceRNA network interactions. These findings not only elucidate its pivotal role in enhancing tumor aggressiveness and other pathological responses but also point to LINC00960 as a promising candidate for prognostic and therapeutic applications in multiple clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_fs", "start_ref": "3", "end_ref": "7"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cheng-Shuo Huang, Jar-Yi Ho, Jung-Hwa Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-Derived LINC00960 and LINC02470 Promote the Epithelial-Mesenchymal Transition and Aggressiveness of Bladder Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9061419"}], "href": "https://doi.org/10.3390/cells9061419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32517366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32517366"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yubo Shi, Bo Yang, Yingchun Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Silencing long non-coding RNA LINC00960 inhibits osteosarcoma proliferation by sponging miR-107 to downregulate SALL4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.01.017"}], "href": "https://doi.org/10.1016/j.bbrc.2022.01.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35033873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35033873"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhipeng Ge, Haibo Liu, Tao Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA 00960 promoted the aggressiveness of lung adenocarcinoma via the miR-124a/SphK1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1996507"}], "href": "https://doi.org/10.1080/21655979.2021.1996507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34738865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34738865"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yaoxing Huang, Qingqing Yan, Danchun Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 960 regulates cancer cell viability, migration and invasion through modulating miR-146a-5p/interleukin 1 receptor associated kinase 1 axis in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2020.1868742"}], "href": "https://doi.org/10.1080/21655979.2020.1868742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33380238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33380238"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hani Sabaie, Marziyeh Mazaheri Moghaddam, Madiheh Mazaheri Moghaddam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA-associated competing endogenous RNA axes in the olfactory epithelium in schizophrenia: a bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-04326-0"}], "href": "https://doi.org/10.1038/s41598-021-04326-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34969953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34969953"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yue Yu, Yuan-Yuan Jia, Meng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTGER3 and MMP-2 play potential roles in diabetic nephropathy via competing endogenous RNA mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Nephrol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12882-020-02194-w"}], "href": "https://doi.org/10.1186/s12882-020-02194-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33435900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33435900"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "XuDong Mao, ShiHan Chen, GongHui Li "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a ten-long noncoding RNA signature for predicting the survival and immune status of patients with bladder urothelial carcinoma based on the GEO database: a superior machine learning model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202553"}], "href": "https://doi.org/10.18632/aging.202553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33621953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33621953"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yingcheng Wu, Jinhuan Wei, Yue Ming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orchestrating a biomarker panel with lncRNAs and mRNAs for predicting survival in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27119"}], "href": "https://doi.org/10.1002/jcb.27119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923223"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marina R Hadjicharalambous, Benoit T Roux, Eszter Csomor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-42292-w"}], "href": "https://doi.org/10.1038/s41598-019-42292-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30988425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30988425"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tingting Yan, Feng Ding, Yan Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Integrated identification of key genes and pathways in Alzheimer's disease via comprehensive bioinformatical analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hereditas (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s41065-019-0101-0"}], "href": "https://doi.org/10.1186/s41065-019-0101-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31346329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31346329"}]}]}]}