{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00964 is emerging as a promising candidate in the arena of non‐coding RNA biomarkers for head and neck squamous cell carcinoma (HNSCC). Notably, in a comprehensive analysis of circulating long non‐coding RNAs in plasma samples from HNSCC patients, LINC00964 was identified among a small panel of transcripts that are significantly up‐regulated compared with healthy controls, suggesting its strong potential for early, minimally invasive detection of this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast to some lncRNAs that have been mechanistically implicated in modulating tumor progression through pathways such as transforming growth factor‑β (TGF‑β) signaling and epithelial‐to‐mesenchymal transition (EMT) in HNSCC"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", the currently reported role of LINC00964 appears to be primarily diagnostic rather than directly involved in these intracellular signaling pathways. Furthermore, large‑scale bioinformatic modeling of lncRNA–miRNA–mRNA interaction networks in breast and other cancers has underscored the diverse regulatory roles of long non‑coding RNAs"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and recent independent studies have reinforced the potential utility of circulating lncRNAs, including LINC00964, as biomarkers in malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings support a role for LINC00964 as a non‐invasive biomarker for HNSCC, while also suggesting that further research is warranted to fully determine whether LINC00964 might also contribute functionally to tumorigenesis or metastasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yao Yao, Xinyuan Chen, Shuai Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating Long Noncoding RNAs as Biomarkers for Predicting Head and Neck Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000494605"}], "href": "https://doi.org/10.1159/000494605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30355951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30355951"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Teng Huang, Wei Huang, Hong Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-018-1418-6"}], "href": "https://doi.org/10.1186/s12967-018-1418-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29490660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29490660"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuhan Zhang, Yongfeng Li, Qing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an lncRNA‑miRNA‑mRNA interaction mechanism in breast cancer based on bioinformatic analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7304"}], "href": "https://doi.org/10.3892/mmr.2017.7304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849135"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yaozhong Liu, Na Liu, Fan Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying ceRNA Networks Associated With the Susceptibility and Persistence of Atrial Fibrillation Through Weighted Gene Co-Expression Network Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.653474"}], "href": "https://doi.org/10.3389/fgene.2021.653474"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34249084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34249084"}]}]}]}