| Name | long intergenic non-protein coding RNA 969 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long noncoding RNA LINC00969 has been shown to play a critical role in the progression of intervertebral disk degeneration by functioning as a competing endogenous RNA. Specifically, LINC00969 is markedly upregulated in the nucleus pulposus tissues and cells isolated from patients with intervertebral disk degeneration. It exerts its function by sponging miR‑335‑3p, thereby reducing the ability of this microRNA to repress its downstream target, thioredoxin‑interacting protein (TXNIP). The resulting upregulation of TXNIP promotes apoptosis in nucleus pulposus cells, implicating LINC00969 as a potential therapeutic target in the treatment of intervertebral disk degeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Yu, Yingjie Hao, Chaojun Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1989"}], "href": "https://doi.org/10.1002/iub.1989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30592131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30592131"}]}]}]}
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| Synonyms | MIR570HG |
| NCBI Gene ID | 440993 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC00969 has 675 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.
Click the + buttons to view associations for LINC00969 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of LINC00969 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of LINC00969 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of LINC00969 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of LINC00969 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of LINC00969 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00969 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of LINC00969 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
