{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of LINC00970 Function in FECD Studies</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Two independent studies investigated the genetic underpinnings of Fuchs endothelial corneal dystrophy (FECD). The first study focused on FECD cases with and without a CTG repeat expansion in the TCF4 gene and identified widespread RNA mis‐splicing as well as differences in the expression of 39 genes between the two patient cohorts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The second study, employing a genome‐wide association approach, identified three novel loci significantly associated with FECD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, neither abstract specifically discusses or provides evidence regarding the function of the long non‐coding RNA LINC00970. Although both studies shed light on various genetic factors and expression differences implicated in FECD, there is no direct mention or analysis of LINC00970’s role in disease pathophysiology. Therefore, based on the provided abstracts, the function of LINC00970 in the context of FECD remains undetermined, and further targeted research would be required to elucidate any potential involvement of this lncRNA in FECD.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eric D Wieben, Ross A Aleff, Xiaojia Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0200005"}], "href": "https://doi.org/10.1371/journal.pone.0200005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29966009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29966009"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Natalie A Afshari, Robert P Igo, Nathan J Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14898"}], "href": "https://doi.org/10.1038/ncomms14898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28358029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28358029"}]}]}]}