{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00973 is emerging as a multifunctional long non‐coding RNA that modulates tumor behavior through several mechanisms in different cancer contexts. In clear‐cell renal cell carcinoma, LINC00973 functions as a competing endogenous RNA by sponging miR‐7109, which results in the transcriptional upregulation of Siglec‑15, a key immune suppressor that facilitates tumor immune evasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LINC00973 is upregulated in response to chemotherapeutic treatment in both normal and cancer cells—a process linked to the activation of the DNA damage response and mitotic arrest—suggesting its involvement in the cellular adaptive response to therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In cetuximab‐resistant colorectal cancer cells, increased LINC00973 expression is associated with enhanced cell viability, reduced apoptosis, and alterations in glucose metabolism, underscoring its contribution to drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in non‐small cell lung cancer, elevated LINC00973 levels have been correlated with poor patient prognosis and the activation of multiple oncogenic signaling pathways, including those governing cell migration, proliferation, and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings suggest that LINC00973 plays a pivotal role in regulating immune responses, mediating chemotherapeutic resistance, and modulating oncogenic signaling, thereby representing a promising diagnostic and therapeutic target in cancer management.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanbin Liu, Xingzhi Li, Changming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14611"}], "href": "https://doi.org/10.1111/cas.14611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32780490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32780490"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eleonora A Braga, Marina V Fridman, Elena A Filippova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222011193"}], "href": "https://doi.org/10.3390/ijms222011193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34681854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34681854"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dmitry S Karpov, Pavel V Spirin, Andrey O Zheltukhin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21218322"}], "href": "https://doi.org/10.3390/ijms21218322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33171937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33171937"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Olga L Zinovieva, Evgenia N Grineva, Maria M Prokofjeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2018.05.021"}], "href": "https://doi.org/10.1016/j.biochi.2018.05.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29870803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29870803"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Changwen Jing, Rong Ma, Haixia Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2004"}], "href": "https://doi.org/10.1002/cam4.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30848094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30848094"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiang Guo, Dan Li, Xiangyu Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.684807"}], "href": "https://doi.org/10.3389/fimmu.2021.684807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34394080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34394080"}]}]}]}