{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00974 is a long intergenic noncoding RNA that exerts oncogenic activities in several contexts by acting as a competing endogenous RNA (ceRNA) to modulate specific microRNAs and downstream effectors. In hepatocellular carcinoma, for example, aberrant promoter hypomethylation leads to increased LINC00974 expression, which in turn sequesters miR‐642 to upregulate KRT19. This ceRNA interaction results in the activation of Notch and TGF‑β signaling pathways, thereby promoting cell proliferation, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oral submucous fibrosis, LINC00974 is similarly upregulated and correlates with enhanced myofibroblast transdifferentiation; its elevated expression augments TGF‑β secretion and phosphorylated Smad2 levels, culminating in increased expression of fibrotic markers such as α‑SMA, collagen, and fibronectin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, LINC00974 has been implicated in cytoskeletal regulation through a LINC00974/miR‑122/RhoA axis, influencing cell migration and actin remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In ovarian cancer, LINC00974 serves as a molecular sponge for miR‑33a, leading to the upregulation of HMGB2, which facilitates cell proliferation, invasion, and epithelial mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Tang, H Zhuo, X Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.518"}], "href": "https://doi.org/10.1038/cddis.2014.518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25476897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25476897"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chih-Yuan Fang, Cheng-Chia Yu, Yi-Wen Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00974 activates TGF-β/Smad signaling to promote oral fibrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jop.12805"}], "href": "https://doi.org/10.1111/jop.12805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30447113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30447113"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Soudeh Ghafouri-Fard, Rezvan Noroozi, Atefe Abak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emerging role of lncRNAs in the regulation of Rho GTPase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2021.111731"}], "href": "https://doi.org/10.1016/j.biopha.2021.111731"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34015583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34015583"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weiwei Liu, Jing Cheng "}, {"type": "b", "children": [{"type": "t", "text": "LINC00974 sponges miR-33a to facilitate cell proliferation, invasion, and EMT of ovarian cancer through HMGB2 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1678-4685-GMB-2021-0224"}], "href": "https://doi.org/10.1590/1678-4685-GMB-2021-0224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35129574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35129574"}]}]}]}