{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as important regulators in several disease processes, particularly in cancer, as demonstrated by multiple studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " While many lncRNAs have been functionally characterized in breast, pancreatic, and hematological cancers, the specific role of LINC00977 remains largely unexplored in these contexts. In contrast, a genome‐wide association study on primary spontaneous pneumothorax (PSP) identified an intergenic single nucleotide polymorphism (rs4733649) located between LINC00824 and LINC00977 that was significantly associated with increased PSP risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " This finding implicates the genomic region harboring LINC00977 as a potential contributor to disease susceptibility, suggesting that LINC00977 may be part of a regulatory network influencing lung structural integrity or repair mechanisms. Although its functional mechanisms have not been directly interrogated, this association underscores the need for further studies to clarify whether LINC00977 itself plays an active role in PSP pathogenesis or serves as a marker for regulatory activity in this locus.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs as prognostic markers in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7828"}], "href": "https://doi.org/10.18632/oncotarget.7828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26942882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26942882"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brian M Wolpin, Cosmeri Rizzato, Peter Kraft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3052"}], "href": "https://doi.org/10.1038/ng.3052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25086665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25086665"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joseph L Wiemels, Kyle M Walsh, Adam J de Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-02596-9"}], "href": "https://doi.org/10.1038/s41467-017-02596-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29348612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29348612"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Enrique Lin-Shiao, Yemin Lan, Julia Welzenbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p63 establishes epithelial enhancers at critical craniofacial development genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aaw0946"}], "href": "https://doi.org/10.1126/sciadv.aaw0946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31049400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31049400"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Inês Sousa, Patrícia Abrantes, Vânia Francisco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multicentric Genome-Wide Association Study for Primary Spontaneous Pneumothorax."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0156103"}], "href": "https://doi.org/10.1371/journal.pone.0156103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27203581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27203581"}]}]}]}