{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00987 has emerged as a multifunctional long non‐coding RNA with context‐dependent roles in human disease. In chronic obstructive pulmonary disease, LINC00987 is downregulated, and its overexpression protects airway epithelial cells from lipopolysaccharide‐induced apoptosis, oxidative stress, inflammation, and autophagy through a competing endogenous RNA mechanism that sponges let‑7b‑5p to maintain SIRT1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In musculoskeletal and autoimmune conditions such as ankylosing spondylitis, LINC00987 was identified as a hub dysregulated lncRNA, suggesting its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In cancers, its role appears diverse. In osteosarcoma, LINC00987 is upregulated and promotes proliferation, migration, and invasion by sponging miR‑376a‑5p to elevate FNBP1 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in acute myeloid leukemia its elevated expression enhances cell growth and invasion via the IGF2BP2/PA2G4 regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, LINC00987 is recognized as a prognostic marker in lung adenocarcinoma and breast cancer, and as a component of an immune‑related axis with A2M, whose dysregulation correlates with tumor progression, immune cell infiltration, and patient survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Collectively, these findings indicate that LINC00987 acts in a disease‐ and context‑specific manner—serving both as a regulator in inflammatory lung injury and as an oncogenic or prognostic factor in various malignancies—thereby representing a promising target for future diagnostic and therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuanyuan Wang, Jingjing Chen, Wei Chen, et al. 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