{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as versatile regulators of gene expression and cellular homeostasis, functioning through diverse mechanisms such as modulating chromatin structure, interacting with transcription factors and RNA‐processing machinery, and influencing post‐transcriptional events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of disease, a growing body of evidence implicates lncRNAs in the pathogenesis and progression of complex disorders. For instance, in high myopia—a leading cause of blindness—research has suggested that a lincRNA (LOC100506035) may contribute to disease susceptibility in a gender‐specific manner, underscoring the potential of lncRNAs to modulate the risk of ocular disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n More recently, oncological studies have begun to unravel the prognostic importance of lncRNAs. Among these, LINC00989 was identified as one component of a ten‐lncRNA signature model designed to predict survival outcomes in breast cancer patients. In this study, LINC00989, alongside other lncRNAs, was shown to associate with overall survival, thereby highlighting its promise as a prognostic biomarker and suggesting that it may play a role in tumorigenesis and cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementary to these observations, analyses in hepatocellular carcinoma have emphasized the importance of epigenetic regulation—including DNA methylation changes that drive aberrant gene expression—in cancer development. Although LINC00989 was not directly examined in these studies, the regulatory paradigms uncovered reinforce the notion that lncRNAs can have profound impacts on cellular transformation and malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings contribute to an emerging paradigm in which lncRNAs such as LINC00989 act as critical modulators in both normal physiology and disease. Their roles in prognostic prediction and disease susceptibility underscore their potential as novel biomarkers and therapeutic targets in diverse pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Rodrigo Coutinho de Almeida, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "TNFRSF12A and a new prognostic model identified from methylation combined with expression profiles to predict overall survival in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr-20-1342"}], "href": "https://doi.org/10.21037/tcr-20-1342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35117914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35117914"}]}]}]}