{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00992 is emerging as an oncogenic long non‐coding RNA with multifaceted roles in cancer progression. In prostate cancer, LINC00992 is highly expressed in tumor tissues and its elevated levels correlate with poor patient outcomes. Functional studies demonstrate that LINC00992 promotes cell proliferation, invasion, migration, metastasis, and angiogenesis. Mechanistically, one study showed that LINC00992 enhances the translation of the oncogene SOX4 by binding to the translation initiation factor EIF4A3, thereby increasing SOX4 protein levels and driving tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate investigation, LINC00992 was found to act as a competing endogenous RNA that binds and sequesters miR-3935, which results in the derepression and subsequent increased expression of GOLM1, further facilitating proliferative and migratory capabilities of prostate cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in prostate cancer, LINC00992 has also been incorporated into a prognostic risk model comprising autophagy-related long non-coding RNAs in breast cancer. Its inclusion in this model underscores a potential involvement in autophagy regulation and hints at broader implications in oncogenic signaling pathways that affect tumor behavior and patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings highlight LINC00992 as a key regulator of cancer cell growth and metastasis, suggesting its promise as both a prognostic biomarker and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Changde Fu, Jun Xin, Wei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00992 exerts oncogenic activities in prostate cancer via regulation of SOX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2021.112855"}], "href": "https://doi.org/10.1016/j.yexcr.2021.112855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34599930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34599930"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianheng Chen, Xiaodong Liu, Kunbin Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-020-07141-4"}], "href": "https://doi.org/10.1186/s12885-020-07141-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32781986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32781986"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoying Li, Feng Jin, Yang Li "}, {"type": "b", "children": [{"type": "t", "text": "A novel autophagy-related lncRNA prognostic risk model for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15980"}], "href": "https://doi.org/10.1111/jcmm.15980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33216456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33216456"}]}]}]}