{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00994 is a long non‐coding RNA with emerging roles in diverse human diseases. In gastrointestinal cancers—specifically pancreatic and gastric cancers—LINC00994 is upregulated and functions in an oncogenic manner by promoting cell proliferation, invasion, migration, and cell cycle progression. Mechanistic studies suggest that LINC00994 acts as a competing endogenous RNA that sequesters miR‑765‑3p, thereby preventing the miRNA from repressing oncogenic targets such as RUNX2, which contributes to the aggressive behavior of cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in type 2 diabetes mellitus, LINC00994 expression is significantly decreased in peripheral blood mononuclear cells from patients compared with healthy controls, suggesting that reduced expression of this lncRNA may contribute to disease pathogenesis and that it might have potential, albeit less robust than other markers, as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, genetic association studies in African American cohorts with inflammatory bowel disease have identified suggestive associations with single-nucleotide polymorphisms near the LINC00994 locus. Although these findings require replication, they point to a potential role for LINC00994 in modulating disease susceptibility in the context of immune-mediated disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies highlight LINC00994 as a multifunctional regulator whose expression and function are context-dependent, promoting oncogenic processes in certain cancers while potentially influencing metabolic and inflammatory conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xuan Zhu, Xing Niu, Chunlin Ge "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of LINC00994 represses malignant behaviors of pancreatic cancer cells: interacting with miR-765-3p/RUNX2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2018.1564566"}], "href": "https://doi.org/10.1080/15384047.2018.1564566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30739523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30739523"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ling Yuan, Tingting Ma, Wenjing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00994 promoted invasion and proliferation of gastric cancer cell via regulating miR-765-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31737214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31737214"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zahra Mansoori, Hamid Ghaedi, Mirsaber Sadatamini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of long non-coding RNAs LINC00523 and LINC00994 in type 2 diabetes in an Iranian cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-018-4276-7"}], "href": "https://doi.org/10.1007/s11033-018-4276-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30043104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30043104"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chengrui Huang, Talin Haritunians, David T Okou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2015.07.065"}], "href": "https://doi.org/10.1053/j.gastro.2015.07.065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26278503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26278503"}]}]}]}