{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00996 is a long intergenic non‐coding RNA that has been implicated in diverse pathological settings, with its expression levels correlating with patient outcomes and disease progression. In colorectal cancer, decreased expression of LINC00996 is significantly associated with distant metastasis and poor overall survival. Functional analyses suggest that LINC00996 may suppress tumorigenesis and metastasis by modulating key signaling pathways—including JAK‐STAT, NF‐κB, HIF‐1, TLR, and PI3K‐AKT—thereby acting in a tumor‐suppressive capacity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In head and neck squamous cell carcinoma, LINC00996 was identified as one component of an eight‐lncRNA prognostic signature that independently predicts clinical outcomes. Its inclusion in the signature and the associated gene co‐expression network further suggest that LINC00996 may be involved in biological processes such as blood vessel development and growth regulation, underscoring its potential role in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In studies of repetitive low‐level blast exposure, LINC00996 was found to be upregulated in whole‐blood samples, with its dysregulation correlating with markers of chronic inflammation and immune response. This finding indicates that LINC00996 might also serve as a biomarker for inflammatory processes following high‐exposure events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in multiple myeloma, LINC00996 forms part of a two‐lncRNA prognostic signature that has significant predictive value for overall survival. Its involvement in a competing endogenous RNA regulatory network further points to a role in the onset and progression of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies highlight a context‐dependent role for LINC00996, acting as a potential tumor suppressor in certain cancers while also serving as a biomarker for immune and inflammatory responses. These multifaceted functions underscore its translational potential in both prognostication and the development of targeted therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hua Ge, Yan Yan, Di Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S173225"}], "href": "https://doi.org/10.2147/OTT.S173225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30147336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30147336"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shao Lina "}, {"type": "b", "children": [{"type": "t", "text": "Identification of hub lncRNAs in head and neck cancer based on weighted gene co-expression network analysis and experiments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.13134"}], "href": "https://doi.org/10.1002/2211-5463.13134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33660438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33660438"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rany Vorn, Katie A Edwards, James Hentig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Pilot Study of Whole-Blood Transcriptomic Analysis to Identify Genes Associated with Repetitive Low-Level Blast Exposure in Career Breachers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomedicines (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biomedicines10030690"}], "href": "https://doi.org/10.3390/biomedicines10030690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35327492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35327492"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sijie Zhou, Jiuyuan Fang, Yan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated Analysis of a Risk Score System Predicting Prognosis and a ceRNA Network for Differentially Expressed lncRNAs in Multiple Myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.00934"}], "href": "https://doi.org/10.3389/fgene.2020.00934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33193574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33193574"}]}]}]}