{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA LINC00997 has emerged as an oncogenic regulator in multiple cancer types. In kidney renal clear cell carcinoma (KIRC), LINC00997 is highly expressed—especially in advanced disease—and its elevated levels correlate with reduced overall and disease‐free survival. Functional studies reveal that LINC00997 promotes cell migration by upregulating metastasis‐associated molecules (VIM, MMP2, and MMP7) via binding with STAT3 and activating the S100A11 promoter."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cervical cancer, increased LINC00997 expression enhances proliferation, migration, invasion, and autophagy through a mechanism that involves acting as a competing endogenous RNA; it sequesters miR-574-3p to upregulate CUL2, thereby activating the MAPK signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Additionally, in clear cell renal cell carcinoma, LINC00997 is up-regulated alongside SNHG3 and shows a positive association with BIRC5 protein expression, suggesting a contributory role in tumor progression, although its direct impact appears less pronounced than that of SNHG3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, higher LINC00997 levels are correlated with both distant metastasis and regional lymph node involvement, further supporting its role in promoting metastatic dissemination through the regulation of metastasis-related genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC00997 contributes to cancer progression by enhancing metastatic potential and altering key signaling pathways, thereby representing a promising prognostic biomarker and therapeutic target in diverse malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Chang, Na Li, Weitang Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00997, a novel long noncoding RNA, contributes to metastasis via regulation of S100A11 in kidney renal clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2019.105590"}], "href": "https://doi.org/10.1016/j.biocel.2019.105590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31442606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31442606"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daming Chu, Tengteng Liu, Yuan Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00997/MicroRNA 574-3p/CUL2 Promotes Cervical Cancer Development via Mitogen-Activated Protein Kinase Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00059-21"}], "href": "https://doi.org/10.1128/MCB.00059-21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34031216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34031216"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhaoyu Xu, Junjie Ye, Pengfei Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG3 promotes the progression of clear cell renal cell carcinoma via regulating BIRC5 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr-21-1802"}], "href": "https://doi.org/10.21037/tcr-21-1802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35116306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35116306"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhiliang Shi, Chenglong Shen, Cheng Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00997 silencing inhibits the progression and metastasis of colorectal cancer by sponging miR-512-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1882164"}], "href": "https://doi.org/10.1080/21655979.2021.1882164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33570445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33570445"}]}]}]}