{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, recent high‐throughput sequencing studies have identified LINC00999 as one of several noncoding genomic regions that are frequently targeted by hepatitis B virus (HBV) DNA integration events. Such integrations, detected in tumor tissues, suggest that disruption or dysregulation of LINC00999 may contribute to the altered transcriptional landscape and malignant progression observed in HBV‐associated liver cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate investigation addressing Kawasaki disease, competitive endogenous RNA (ceRNA) network analysis was performed to identify dysregulated long noncoding RNAs, microRNAs, and genes involved in the disease’s molecular mechanisms. Although detailed functional effects were not fully elaborated in the abstract, LINC00999 emerged as one of the differentially expressed lncRNAs participating in such ceRNA circuits. Its involvement implies a potential role in post‐transcriptional gene regulation processes that may affect inflammatory or immune pathways in Kawasaki disease; however, the precise functional contribution of LINC00999 in this context remains to be further elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zebao He, Jiansheng Zhu, Jinggang Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11074"}], "href": "https://doi.org/10.3892/mmr.2020.11074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319639"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Changsheng Guo, Yuanqing Hua, Zuanhao Qian "}, {"type": "b", "children": [{"type": "t", "text": "Differentially expressed genes, lncRNAs, and competing endogenous RNAs in Kawasaki disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.11169"}], "href": "https://doi.org/10.7717/peerj.11169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34026343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34026343"}]}]}]}