{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n An integrated review of recent findings indicates that while dysregulation of key components of the miRNA biogenesis pathway—such as AGO2, DCR1, and STAT3—may drive inflammation in post‐traumatic stress disorder (PTSD)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", long non‐coding RNAs (lncRNAs) are emerging as important players in other disease contexts. In lung adenocarcinoma, for example, LINC01002 was identified among a panel of nine prognostic lncRNAs whose expression levels are significantly altered in tumor tissues relative to normal controls."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Within a constructed miRNA–lncRNA–mRNA regulatory network, LINC01002 is postulated to function as a competing endogenous RNA (ceRNA) that may modulate miRNA availability and thereby influence downstream gene expression critical for tumor progression. This suggests that altered LINC01002 expression might not only serve as a prognostic biomarker in lung adenocarcinoma but also could be a potential therapeutic target through its involvement in fine‐tuning cancer‐related post‐transcriptional regulatory circuits.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Bam, X Yang, E E Zumbrun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2017.185"}], "href": "https://doi.org/10.1038/tp.2017.185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28850112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28850112"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "D-S Li, J-L Ainiwaer, I Sheyhiding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key long non-coding RNAs as competing endogenous RNAs for miRNA-mRNA in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27338053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27338053"}]}]}]}