{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01003 has been implicated in the regulation of diverse oncogenic processes in hematological malignancies. In multiple myeloma, LINC01003 is downregulated, and its upregulation suppresses cell viability and adhesion while promoting apoptosis, effects that are mediated via sponging of miR-33a-5p and subsequent downregulation of its target gene, PIM1. In vivo, enhanced LINC01003 expression led to reduced tumor growth in xenograft models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, expression profiling in acute myeloid leukemia (AML) identified LINC01003 as one of four long noncoding RNAs with independent prognostic value. A risk scoring system based on these lncRNAs, including LINC01003, stratified patients into high- and low-risk groups, with functional analyses suggesting involvement in pathways such as mTOR signaling, apoptosis, and immune-related receptor pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " These findings indicate that LINC01003 may function as a tumor suppressor by modulating critical molecular networks in MM and serve as a valuable prognostic biomarker in AML.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Linlin Wu, Liang Xia, Xiaowen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01003 suppresses the development of multiple myeloma by targeting miR-33a-5p/PIM1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2021.106565"}], "href": "https://doi.org/10.1016/j.leukres.2021.106565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33865032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33865032"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Zeng, Haibing Wu, Minchao Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a 4 lncRNAs-based prognostic risk scoring system in adults with acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2019.106261"}], "href": "https://doi.org/10.1016/j.leukres.2019.106261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31739140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31739140"}]}]}]}