{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies underscore the diverse roles of non‐coding RNAs in human disease. For example, while one investigation into the molecular basis of cognitive impairment in schizophrenia revealed dysregulation of the SMAD pathway in neuronal tissue (from olfactory epithelium)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", another study focusing on pituitary adenoma uncovered a specific function for the long intergenic non‐protein coding RNA LINC01004. In pituitary adenoma cells, LINC01004 was found to be aberrantly up‐regulated, and functional assays demonstrated that its increased expression promoted malignant behaviors in vitro as well as tumor growth in vivo. Mechanistic analyses provided evidence that LINC01004 acts as a molecular sponge for miR‑323a‑3p and miR‑136‑5p, thereby enhancing the expression of RCN2 and contributing to the oncogenic process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although other contexts of neural dysfunction, such as those explored in the schizophrenia study (and in related reports"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", did not address LINC01004 directly, the demonstration of its regulatory role in pituitary adenoma emphasizes the broad relevance of non‐coding RNAs in disease pathogenesis and highlights LINC01004 as a potential target for therapeutic intervention in oncological settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Horiuchi, M A Kondo, K Okada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2016.154"}], "href": "https://doi.org/10.1038/tp.2016.154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27727244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27727244"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peng Qiu, Jiancheng Bi, Jia Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01004 promotes malignant behaviors of pituitary adenoma via miR-323a-3p/136-5p/RCN2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.153884"}], "href": "https://doi.org/10.1016/j.prp.2022.153884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35490653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35490653"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mei Chen, Zhenyu Nie, Yan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A New Ferroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.699804"}], "href": "https://doi.org/10.3389/fcell.2021.699804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34869304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34869304"}]}]}]}