{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01006 is a long intergenic non‐coding RNA whose dysregulated expression has been observed in a broad spectrum of diseases, including psychiatric conditions and various cancers. In one genome‐wide association study of bipolar disorder and schizophrenia in Latino populations, an intragenic signal that included LINC01006 was linked to disease risk, suggesting that variants within or near this lncRNA may contribute to the genetic architecture of neuropsychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oncology, altered LINC01006 expression has been reported in several tumor types. In gastric cancer, for instance, LINC01006 levels are significantly lower in cancer tissues compared to normal controls and correlate with clinicopathological features, indicating its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Conversely, multiple independent studies in hepatocellular, pancreatic, prostate, and colon cancers have demonstrated that LINC01006 is frequently up‐regulated, where it functions as a competing endogenous RNA for distinct microRNAs. Specifically, in hepatocellular carcinoma, LINC01006 promotes tumor progression by sequestering miR‐194‐5p and miR‐433‐3p, which in turn modulate the expression of oncogenic targets such as CADM1 and CBX3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In pancreatic cancer, LINC01006 enhances cell proliferation and metastasis via a miR‐2682‐5p/HOXB8 axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in prostate cancer it exerts its oncogenic effect by sponging miR‐34a‐5p to upregulate DAAM1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in colon cancer, its overexpression is associated with increased tumor cell proliferation and invasiveness, further underscoring its potential as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, LINC01006 appears to play a context‐dependent role. Its altered expression can either indicate a disrupted regulatory mechanism in neuropsychiatric disorders or drive oncogenesis by modulating microRNA availability and, consequently, the expression of downstream target genes. These studies collectively suggest that LINC01006 may serve both as a potential biomarker for disease diagnosis/prognosis and as a therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Suzanne Gonzalez, Jayanta Gupta, Erika Villa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bipolar Disord (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bdi.12438"}], "href": "https://doi.org/10.1111/bdi.12438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27759212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27759212"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoqin Zhu, Fang Chen, Yongfu Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 1006 used as a potential novel biomarker of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-170273"}], "href": "https://doi.org/10.3233/CBM-170273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29060927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29060927"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhaoxia Sun, Li Zhao, Shuang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of long non-coding RNA LINC01006 represses the development of hepatocellular carcinoma by modulating the miR-194-5p/CADM1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hepatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.aohep.2021.100571"}], "href": "https://doi.org/10.1016/j.aohep.2021.100571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34718169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34718169"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yaobo Song, Shuang Wang, Xiangming Cheng "}, {"type": "b", "children": [{"type": "t", "text": "LINC01006 regulates the proliferation, migration and invasion of hepatocellular carcinoma cells through regulating miR-433-3p/CBX3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hepatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.aohep.2021.100343"}], "href": "https://doi.org/10.1016/j.aohep.2021.100343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33781916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33781916"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Luyang Zhang, Yunjian Wang, Ling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01006 promotes cell proliferation and metastasis in pancreatic cancer via miR-2682-5p/HOXB8 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-1036-2"}], "href": "https://doi.org/10.1186/s12935-019-1036-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31827394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31827394"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Enhui Ma, Qianqian Wang, Jinhua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01006 facilitates cell proliferation, migration and invasion in prostate cancer through targeting miR-34a-5p to up-regulate DAAM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01577-1"}], "href": "https://doi.org/10.1186/s12935-020-01577-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33088221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33088221"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yaoqiang Wu, Bo Yu, Yaping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01006 and miR-3199 Serve as Novel Markers of Poor Prognosis in Colon Cancer and Regulate Cell Proliferation, Migration and Invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S334701"}], "href": "https://doi.org/10.2147/IJGM.S334701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35210837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35210837"}]}]}]}