{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01010 has emerged as an important long noncoding RNA with implications in cancer progression. In lung cancer, experimental evidence indicates that downregulation of LINC01010 promotes cell migration and invasion, supporting a tumor‐suppressive role in curbing metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In breast cancer, LINC01010 was incorporated into an immune‐related prognostic signature, with decreased expression observed in advanced T and M stages. This finding suggests that proper expression of LINC01010 may help limit disease aggressiveness and could serve as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in neuroblastoma, LINC01010 was identified as part of a risk signature significantly associated with patient survival outcomes, further underscoring its potential as a prognostic indicator across different tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that LINC01010 may act as a tumor suppressor whose dysregulation is linked to enhanced malignancy and poorer prognosis, thereby presenting a candidate for further exploration as both a biomarker and potential therapeutic target in diverse cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qing Cao, Zewen Dong, Shuzhen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a metastasis-associated ceRNA network reveals a prognostic signature in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01295-8"}], "href": "https://doi.org/10.1186/s12935-020-01295-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32518519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32518519"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ran Xiao, Meng Yang, Yuanyuan Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Five Immune-Related lncRNAs Predicting Survival and Tumor Microenvironment Characteristics in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6676692"}], "href": "https://doi.org/10.1155/2021/6676692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33727952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33727952"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Gao, Peng Lin, Peng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel risk signature that combines 10 long noncoding RNAs to predict neuroblastoma prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29277"}], "href": "https://doi.org/10.1002/jcp.29277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31612488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31612488"}]}]}]}