{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long non‐coding RNA LINC01013 plays multifaceted roles in several pathophysiological processes. In anaplastic large‐cell lymphoma, LINC01013 is highly expressed in invasive cells and promotes tumor cell invasion by activating epithelial‐to‐mesenchymal transition (EMT) through upregulation of the transcription factor snail and the extracellular matrix protein fibronectin, suggesting its potential as a metastasis marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In childhood B‐lineage acute lymphoblastic leukemia, differential expression of LINC01013 has been associated with early relapse and increased mortality, supporting its promise as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In calcific aortic valve disease, LINC01013 acts as a super‐enhancer–derived lncRNA that modulates fibrogenesis. It functions as a decoy for the negative transcription elongation factor NELF‐E, thereby controlling the expression of CCN2 (CTGF) within a transforming growth factor beta 1 (TGFB1) network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LINC01013 contributes to the maintenance of cancer stem cell properties by sponging miR‐6795-5p, which in turn releases FMNL3 to promote cell proliferation, colony formation, and self‐renewal."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, LINC01013—also known as Aerrie in the context of vascular biology—has been implicated in maintaining genomic stability in endothelial cells. It interacts with the protein YBX1 to facilitate proper DNA damage signaling and repair, thereby preserving angiogenesis, cellular migration, and barrier function during aging."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in mesenchymal stem cells, transcription factors DLX5 and HOXC8 negatively regulate LINC01013 to enhance chondrogenic differentiation and cartilage formation, indicating that its suppression may favor tissue regeneration strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the multifunctional nature of LINC01013, highlighting its involvement in cancer cell invasion and metastasis, prognostic significance in hematological malignancies, regulation of fibrogenesis, cancer stem cell modulation, genomic stability in vascular cells, and the promotion of chondrogenic differentiation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-00382-7"}], "href": "https://doi.org/10.1038/s41598-017-00382-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28331184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28331184"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Diego Alberto Bárcenas-López, Juan Carlos Núñez-Enríquez, Alfredo Hidalgo-Miranda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11030302"}], "href": "https://doi.org/10.3390/genes11030302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32183133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32183133"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1010010"}], "href": "https://doi.org/10.1371/journal.pgen.1010010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35041643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35041643"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wanli Wang, Shicheng Xu, Ying Di, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmab040"}], "href": "https://doi.org/10.1093/abbs/gmab040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33847733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33847733"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tan Phát Pham, Diewertje I Bink, Laura Stanicek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2020.619079"}], "href": "https://doi.org/10.3389/fcell.2020.619079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33505972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33505972"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Haoqing Yang, Yangyang Cao, Jianpeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-020-01791-8"}], "href": "https://doi.org/10.1186/s13287-020-01791-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32631410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32631410"}]}]}]}