{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies indicate that LINC01014 plays a crucial role in modulating drug resistance in esophageal squamous cell carcinoma. In one study, overexpression of LINC01014 was shown to inhibit gefitinib‐induced apoptosis in FLO‐1 cells via activation of the PI3K–AKT–mTOR signaling pathway, thereby enhancing chemoresistance. Conversely, silencing LINC01014 promoted apoptosis and increased sensitivity to gefitinib, suggesting its potential as a therapeutic target to overcome resistance mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Additionally, comprehensive reviews of long non‐coding RNAs in ESCC have highlighted that lncRNAs, including LINC01014, are involved in key oncogenic pathways such as PI3K and Wnt/β-catenin. These pathways are critical in driving tumor recurrence, metastasis, and reducing chemotherapeutic efficacy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao Fu, Guanghui Cui, Shuaishuai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc01014 regulates gefitinib resistance in oesophagus cancer via EGFR-PI3K-AKT-mTOR signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14860"}], "href": "https://doi.org/10.1111/jcmm.14860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31785047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31785047"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Uttam Sharma, Masang Murmu, Tushar Singh Barwal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/curroncol29040189"}], "href": "https://doi.org/10.3390/curroncol29040189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35448163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35448163"}]}]}]}