{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In human testes, recent findings reveal a novel role for a subset of long non‐coding RNAs in piRNA biogenesis. Although LINC01015 is not explicitly mentioned by name in the study (1), the work shows that approximately 16% of generated piRNAs map to annotated lncRNA genes. This observation suggests that, like other lncRNAs, LINC01015 may serve as a precursor transcript from which piRNAs are derived. These piRNAs are then implicated in the silencing of mobile genetic elements – particularly young long terminal repeat families and endogenous retroviruses – through mechanisms that include the ping-pong amplification cycle. In summary, if LINC01015 is among the lncRNAs involved, it likely contributes to maintaining genomic stability by providing precursor sequences for piRNA production, which in turn repress the activity of mobile elements (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongseok Ha, Jimin Song, Shuoguo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-15-545"}], "href": "https://doi.org/10.1186/1471-2164-15-545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24981367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24981367"}]}]}]}