{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01018 has emerged as a multifunctional long non‐coding RNA whose dysregulation is associated with several human diseases, particularly diverse cancers and conditions with inflammatory or metabolic components. In endometriosis, LINC01018 appears to function as a competing endogenous RNA (ceRNA) that sponges hsa‐miR‑182‑5p, thereby de‐repressing target genes (such as CHL1) that are involved in inflammation‐related pathways and potentially drive disease development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, LINC01018 was identified among a panel of differentially expressed lncRNAs, supporting its candidature as a diagnostic or prognostic biomarker in the disease context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In acute myeloid leukemia (AML), reduced LINC01018 expression has been linked to enhanced cell proliferation and reduced apoptosis. Experimental overexpression of LINC01018 restored PDCD4 levels through sponging of miR‑499a‑5p, resulting in suppressed proliferation and promotion of programmed cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the setting of hepatitis B virus (HBV)–associated hepatocellular carcinoma, LINC01018 is a component of a ceRNA network (together with hsa‑miR‑574‑5p and the glucose‑6‑phosphatase catalytic subunit) that may critically influence tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Studies using a humanized mouse model have further demonstrated that LINC01018 can regulate the expression of genes involved in fatty acid oxidation, acting via its interaction with the RNA‐binding protein HuR; this finding suggests an in vivo role for LINC01018 in metabolic regulation, particularly in the context of obesity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In another hepatocellular carcinoma model, LINC01018 was shown to act as a molecular sponge for miR‑182‑5p, leading to the upregulation of the transcription factor FOXO1. This axis contributed to reduced cell proliferation and enhanced apoptosis, underscoring its tumor‑suppressive potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in gastric cancer, LINC01018 is part of a four‑lncRNA signature that correlates with improved overall patient survival, further emphasizing its potential utility as a prognostic biomarker across different cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies support a model in which LINC01018 functions predominantly as a ceRNA that modulates gene expression by sequestering specific microRNAs. Its regulatory actions influence key cellular processes—including proliferation, apoptosis, inflammatory signaling, and metabolic pathways—thereby positioning LINC01018 as a promising target for diagnostic and therapeutic interventions in various diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Jiang, Mengmeng Zhang, Sixue Wang, et al. 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