{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01029 is a long non‐coding RNA identified as a component of gene networks implicated in diverse pathological processes. In one study examining the genetic overlap between schizophrenia and tobacco smoking behaviors, LINC01029 was among several non‐coding RNAs that shared genetic liability with nicotine dependence and schizophrenia. These shared genes were enriched in pathways related to calcium signaling, long‐term potentiation, and neuroactive ligand–receptor interactions, processes that are critical for cognitive function and neuronal plasticity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study focused on colorectal cancer, LINC01029 was discovered through integrated bioinformatics analyses and network clustering, where it appeared as part of non‐coding RNA networks potentially involved in regulating gene expression in cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings suggest that LINC01029 may play a role in modulating key signaling pathways and gene regulatory mechanisms in both neuropsychiatric and oncologic contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jingchun Chen, Silviu-Alin Bacanu, Hui Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Relationship between Schizophrenia and Nicotine Dependence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep25671"}], "href": "https://doi.org/10.1038/srep25671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27164557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27164557"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fahimeh Fattahi, Jafar Kiani, Mohsen Khosravi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enrichment of Up-regulated and Down-regulated Gene Clusters Using Gene Ontology, miRNAs and lncRNAs in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207321666191010114149"}], "href": "https://doi.org/10.2174/1386207321666191010114149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31654507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31654507"}]}]}]}