{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA 1048 (LINC01048) has emerged as an oncogenic factor in cutaneous squamous cell carcinoma (CSCC). Elevated expression of LINC01048 is observed in CSCC tissues and recurrence samples compared to adjacent normal tissues, and its high levels correlate with reduced overall and disease‐free survival, making it a poor prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistically, the transcription factor USF1 activates LINC01048, which in turn facilitates the binding of the RNA-binding protein TAF15 to the YAP1 promoter. This enhances YAP1 transcription and results in suppression of the Hippo pathway, thereby promoting CSCC cell proliferation and inhibiting apoptosis. These findings not only highlight the pivotal role of LINC01048 in CSCC progression but also suggest that lncRNAs may serve as promising biomarkers and therapeutic targets. Moreover, the broader context of lncRNA deregulation, as illustrated by studies detailing altered non-coding RNA profiles in human adipocytes following exposure to bisphenols (BPA and its analogs), underscores the wide-ranging impact of lncRNAs in modulating cellular processes and disease states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lezi Chen, Quan Chen, Shifeng Kuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1516-2"}], "href": "https://doi.org/10.1038/s41419-019-1516-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30931936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30931936"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yujia Wang, Bensen Sun, Xiang Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Roles of lncRNA in Cutaneous Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.00158"}], "href": "https://doi.org/10.3389/fonc.2020.00158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32185124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32185124"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marie Verbanck, Mickaël Canouil, Audrey Leloire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0179583"}], "href": "https://doi.org/10.1371/journal.pone.0179583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28628672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28628672"}]}]}]}