{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01050 is a long non‐coding RNA that is transcriptionally activated by the oncogenic transcription factor c-Myc and is significantly upregulated in gastric cancer, where its high expression is associated with a poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional studies have demonstrated that overexpression of LINC01050 promotes gastric cancer cell proliferation, migration, invasion, and epithelial–mesenchymal transition in vitro, as well as enhanced tumor growth and metastasis in vivo. Mechanistically, LINC01050 acts as a molecular sponge for miR-7161-3p, thereby attenuating the microRNA-mediated translational repression of SPZ1, which facilitates gastric cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Consequently, LINC01050 represents a potential therapeutic target in the management of gastric cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ziwei Ji, Tianbin Tang, Mengxia Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C-Myc-activated long non-coding RNA LINC01050 promotes gastric cancer growth and metastasis by sponging miR-7161-3p to regulate SPZ1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-02155-7"}], "href": "https://doi.org/10.1186/s13046-021-02155-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34749766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34749766"}]}]}]}