{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies underscore the importance of long noncoding RNAs (lncRNAs) in both complex genetic phenomena and cancer prognosis. One investigation analyzing parent‐of‐origin effects in a large human pedigree demonstrated that genetic loci—often residing in imprinted regions—can exert differential effects depending on whether they are maternally or paternally inherited."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although this study did not focus explicitly on LINC01055, it contributes to a broader understanding of how imprinted lncRNAs might influence disease‐relevant traits. In the context of colorectal cancer (CRC), bioinformatic analyses have been applied to screen for immune‐related lncRNAs with prognostic relevance. One such study established a risk scoring model based on several immune‐related lncRNAs but did not specifically highlight LINC01055."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, a separate transcriptome analysis of CRC patients identified a panel of prognostic lncRNAs, in which high expression of LINC01055 was significantly associated with better overall survival, suggesting a potentially protective role in CRC prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings imply that while the regulatory complexity of imprinted loci is emerging in diverse contexts, LINC01055 in particular may serve as a favorable prognostic biomarker in colorectal cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sahar V Mozaffari, Jeanne M DeCara, Sanjiv J Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-018-0267-4"}], "href": "https://doi.org/10.1038/s42003-018-0267-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30675526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30675526"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fengxia Qin, Houxi Xu, Guoli Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.658736"}], "href": "https://doi.org/10.3389/fgene.2021.658736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33959151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33959151"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuqi Sun, Peng Peng, Lanlan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of lnc RNAs Related to Prognosis of Patients With Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820962120"}], "href": "https://doi.org/10.1177/1533033820962120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33111631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33111631"}]}]}]}