{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01060 is a long non‐coding RNA that exhibits diverse, context‐dependent roles in cancer progression and treatment‐related toxicities. In pancreatic cancer, LINC01060 acts as a tumor suppressor; its lower expression is associated with poorer prognosis and enhanced tumor cell proliferation and invasion. Mechanistically, LINC01060 regulates vinculin expression and modulates focal adhesion turnover, which in turn impacts the activation of downstream signaling molecules such as FAK and ERK, thereby inhibiting malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer patients treated with trastuzumab, genetic variants in LINC01060 have been linked to declines in left ventricular ejection fraction, suggesting a potential role for this lncRNA in mediating cardiotoxicity during combination chemotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In glioma, LINC01060 is upregulated in tumor cells following transfer via exosomes from hypoxic glioma stem cells. Once elevated, LINC01060 physically interacts with the transcription factor MZF1, enhancing its nuclear translocation and promoting c‐Myc–mediated transcriptional activities. This activation further increases hypoxia-inducible factor-1α levels, thereby establishing a positive feedback loop that drives glioma progression and is associated with higher tumor grade and poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiuhui Shi, Xingjun Guo, Xu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Linc01060 induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.06.015"}], "href": "https://doi.org/10.1016/j.canlet.2018.06.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29913236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29913236"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel J Serie, Julia E Crook, Brian M Necela, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0000000000000302"}], "href": "https://doi.org/10.1097/FPC.0000000000000302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28763429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28763429"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junjun Li, Tingting Liao, Hongya Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1α Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-20-2270"}], "href": "https://doi.org/10.1158/0008-5472.CAN-20-2270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33158815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33158815"}]}]}]}