{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01061, a long non‐coding RNA, is emerging as a multifaceted regulator in several pathological contexts, including various cancers and viral infections. In cholangiocarcinoma, LINC01061 is upregulated and primarily located in the cytoplasm where it functions as a competing endogenous RNA; by sponging miR‑612 it upregulates SEMA4D expression, thereby promoting cell proliferation, migration, and inhibiting apoptosis, which underlines its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of virus-induced oncogenesis, such as that driven by Kaposi’s sarcoma–associated herpesvirus, LINC01061 (also known as KIKAT) interacts with the histone demethylase KDM4A to mediate its displacement from the transcription start site of the AMOT promoter. This repositioning enhances AMOT transactivation and promotes endothelial cell migration, suggesting an epigenetic mechanism that may contribute to KDM4A-driven oncogenicity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, studies in papillary thyroid cancer have revealed that LINC01061 is genomically amplified, leading to elevated expression levels that correlate with aggressive clinical characteristics. Mechanistically, LINC01061 acts as a sponge for miR‑4316, which in turn promotes the expression of E2F6, facilitating cell cycle progression, proliferation, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementary evidence in gastric cancer further supports an oncogenic role for LINC01061, where its overexpression is associated with enhanced cell growth, altered cell cycle regulation, epithelial–mesenchymal transition (EMT) with concomitant β‑catenin modulation, and poorer patient survival. This correlation underscores its potential utility as a novel diagnostic and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, a genetic association study has identified a single nucleotide polymorphism located between the FABP2 and LINC01061 genes that is linked to a predisposition to severe forms of tick‑borne encephalitis, suggesting that regulatory elements related to LINC01061 could influence host susceptibility to this viral infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, a broader review of cholangiopathies highlights the significance of long non‑coding RNAs—including LINC01061—in modulating gene expression and disease progression, thereby representing attractive targets for novel therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aijun Yu, Luwen Zhao, Qingmin Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01061 sponges miR-612 to regulate the oncogenic role of SEMA4D in cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.125"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30967271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30967271"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wan-Shan Yang, Wayne W Yeh, Mel Campbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA KIKAT/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1009670"}], "href": "https://doi.org/10.1371/journal.ppat.1009670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34111227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34111227"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinhua Wu, Yan Yan, Hang Li, et al. 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